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7, 8 Death of a significant number of RGCs most likely reduces the number of the axons forming the optic nerve

While this can be an intended effect, it's important not to reduce your intake of essential daily nutrients

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of between 2.3 and 10.2 per 100,000 people over 50 years of age

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It would therefore be interesting to determine if the opposite approach, i.e., simultaneously inhibiting ARC AgRP/NPY neurons and activating ARC POMC neurons, additively reduces food intake and leads to weight loss in the chronic setting as this would be therapeutically relevant