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doi: 10.1016/j.cbi.2018.04.023 52 TianXRuQXiongQWenRChenY

Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders

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(1998) showed in rat pituitary cell assays that ipamorelin had an EC50 in the low nanomolar range for GH release, comparable to GHRP-6, but crucially did not stimulate ACTH release even at supraphysiological concentrations, distinguishing it from hexarelin and GHRP-6 at the receptor pharmacology level

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