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KPV's smaller molecule size and more targeted mechanism may contribute to its cleaner anecdotal side effect profile, though long-term human data do not exist for either compound
Advances in Nutrition , 3(5), 618-626
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A 2019 randomized controlled trial of lipotropic injections (methionine, inositol, choline, B12) versus saline placebo in 120 participants on ad libitum diets found 0.8 kg (1.76 pounds) difference at 12 weeks, not statistically significant (p=0.18) (Karbalay-Doust et al., Journal of Research in Medical Sciences , 2019)
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