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It is a sympathomimetic amine that suppresses appetite through a completely different mechanism, primarily by stimulating norepinephrine release in the brain

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Even mild but persistent symptoms can lead to treatment discontinuation, particularly in non-diabetic individuals using these agents primarily for weight management, who may have lower thresholds for tolerability than diabetic patients

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This observation is consistent with a previous report demonstrating that long-term HFD consumption impaired liver regeneration in C57BL/6 mice through suppression of NF-B activation 44