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Aged mice were intraperitoneally injected with 5 mg/kg FOXO4-DRI or PBS as a control every other day for three administrations, and effects were assessed 30 days post-treatment

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It is studied in laboratory research for its role in fat oxidation, lipolysis, adipose tissue metabolism, lipogenesis inhibition, and cartilage repair pathway biology without the IGF-1 stimulation, insulin resistance, or receptor-mediated proliferative effects associated with full-length hGH

Full-length human growth hormone represents the central mediator of this axis and is commonly used in research to examine direct growth hormone receptor activation and downstream signaling networks such as JAK2/STAT pathways