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The theoretical advantage of tirzepatide is its dual GLP-1/GIP receptor activation

Taniguchi H, Fernandez AF, Setien F, Ropero S, Ballestar E, Villanueva A, Yamamoto H, Imai K, Shinomura Y, Esteller M (2009) Epigenetic inactivation of the circadian clock gene BMAL1 in hematologic malignancies

In the landmark STEP trials, semaglutide produced average weight loss of approximately 15% of body weight over 68 weeks

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I remind patients that there are options here, such as being on medication intermittently or cycling on and off medication

Victoza may be used off-label for weight management, but its active ingredient is also available as branded Saxenda, indicated specifically for weight loss