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In fact, GLP-1 receptor agonists have a more favourable profile in terms of glycaemic control and body weight reduction, whereas in terms of hard clinical endpoints SGLT-2 inhibitors predominantly reduce hospitalisations for worsening HF and ameliorate progression of CKD, while GLP-1 receptor agonists may have more pronounced effects against myocardial infarction and ischaemic stroke [4]

For studies where cortisol or prolactin elevation would confound the primary readout most mechanistic GH studies that cleanliness isnt a minor methodological preference

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Diabetes, metabolic syndrome and obesity : targets and therapy, 14, 26192629

Real-world results vary based on dose tolerance, adherence, nutrition, physical activity, medication access, side effects, sleep, alcohol intake, stress, medical history, and follow-up consistency

That's mechanism