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Poor sleep can disrupt the hormones that regulate hunger and fullness, making appetite harder to control
A review in which progestin-only contraceptives were studied highlighted the importance of the follow-up period, since longer follow-up periods (2-3 years) showed twice the degree of weight gain as compared to shorter studies (1 year) (239)
It does mean the evidence base for a specific compounded preparation is different from the evidence base for an FDA-approved finished drug product
They may suggest pausing at the current dose for longer before escalating again
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This is the single biggest factor
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