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Common adverse effects include: Gastrointestinal symptoms : Nausea, vomiting, diarrhoea, constipation, and abdominal discomfort affect 3050% of users, particularly during dose escalation

Adv Ther 28(3):213226 Frias JP, Nauck MA, Van J, Kutner ME, Cui X, Benson C et al (2018) Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator-controlled phase 2 trial

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Sustained moderate activity like hiking is one of the most effective ways to preserve muscle mass during weight loss, support cardiovascular health, and improve insulin sensitivity, all goals that align directly with what tirzepatide and semaglutide are doing metabolically

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