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In this study, we sought to test the hypothesis that ketamine administration in patients with depression leads to an acute increase in glutamatergic activity in the ACC, as measured by 1 H-fMRS, and that pretreatment with the opioid receptor antagonist naltrexone attenuates this increase

Biochimica et biophysica acta , 1830 (5), 31433153

Many patients report reduced discomfort or improved function within 1-2 weeks

The kynurenine pathway: a finger in every pie

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The latter indicates that traditional Chinese medicine has also been applied in clinical research