step up trial semaglutide ECO 2026 The SELECT Trial - A

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High Early Discontinuation Rates Alarmingly, around 63% of individuals stop GLP-1 injections within the first month, primarily due to adverse side effects such as nausea, gastrointestinal discomfort, and cost-related factors

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10.1016/S0140-6736(18)32261-X 32 HolmanR

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It was designed to mimic the effects of endogenous GHRH while offering greater stability and prolonged biological activity compared to the natural hormone, which is rapidly degraded in the body