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Open biology, 11 (3), 200411
A thorough understanding of the physiological conditions of the digestive system is essential for the targeted design and optimization of MNMs, enabling them to overcome these challenges more effectively
Aust N Z J Psychiatry 2017;51:241-9
PMID: 23782145
FIGURE 12 4.1.1 Imidazo[1,2-a] pyrazine derivatives An HTS campaign and subsequent structural optimization of Compound 37 , an initially identified PDE10A inhibitor, led to the discovery of imidazo[1,2-a] pyrazine-containing Compound 40 , a potent and selective PDE10A inhibitor exhibiting promising in vivo efficacy across various rodent behavioral models of schizophrenia, along with favorable pharmacokinetic properties in rats
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