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What Happens After Stopping GLP-1s A study found that one year after stopping semaglutide (the active ingredient in Ozempic), patients regained two-thirds of their prior weight loss over the following 52 weeks

Most people land on this comparison because they're dealing with one, or several, of a handful of specific problems: Appetite and hunger that won't quiet down

In theory, targeting both pathways simultaneously could produce greater appetite suppression than either drug alone

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DPP-4 inhibitors, or gliptins, increase GLP-1 levels by blocking the enzyme which inactivates GLP-1