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Stopping semaglutide abruptly often leads to rapid rebound, with reports of a 50% increase in appetite within the first week, and about 70% of patients experience weight regain after abrupt discontinuation
When administered as a once-weekly subcutaneous injection, semaglutide binds to GLP-1 receptors found throughout the body, particularly in the pancreas, brain, and gastrointestinal tract
If you are unable to keep fluids down for more than 24 hours due to vomiting or diarrhoea, seek medical advice promptly to prevent dehydration and potential kidney problems
These improvements appear to occur primarily through weight loss and reduction in ectopic fat deposition in liver and muscle tissue, rather than through direct insulin-sensitizing effects on cellular receptors
Regular follow-up appointments monitor progress, adjust interventions, and provide ongoing education and motivation
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