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Research in aging mouse models shows that MOTS-c administration suppresses SASP markers and reduces the burden of senescent cells in metabolically active tissues [2]
Papaccio, F., DArino, A., Caputo, S., & Bellei, B
Global cardiovascular reserve dysfunction in heart failure with preserved ejection fraction
Any changes in the rats body composition were measured by time-domain nuclear magnetic resonance (TD NMR), as well as through the collection of organ and muscle tissue [3]
Eisenberg T, Knauer H, Schauer A, Bttner S, Ruckenstuhl C, Carmona-Gutierrez D, Ring J, Schroeder S, Magnes C, Antonacci L, Fussi H, Deszcz L, Hartl R, Schraml E, Criollo A, Megalou E, Weiskopf D, Laun P, Heeren G, Breitenbach M, Grubeck-Loebenstein B, Herker E, Fahrenkrog B, Frhlich KU, Sinner F, Tavernarakis N, Minois N, Kroemer G, Madeo F (2009) Induction of autophagy by spermidine promotes longevity