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This distinguishes it from GLP-1 agonists like semaglutide, which produce greater weight loss but carry a risk of muscle wasting

Massive effects on gene expression

hepatocyte-specific SIRT1 deletion primarily aggravates metabolic dysfunction

Normal saline (0.9% sodium chloride) is sometimes used because it matches the tonicity of nasal mucosal fluids, reducing irritation

Amylin and GLP-1 pathways are known to interact within the central nervous system, particularly in the hypothalamus and brainstem areas critical to hunger and satiety signalling

doi: 10.1007/s11102-020-01029-z 75 StefaneanuLKovacsKHorvathELloydRVBuchfelderMFahlbuschRet al