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Proposed mechanisms of MOTS-c: Activates AMPK Improves insulin sensitivity Enhances glucose utilization Increases metabolic flexibility Improves mitochondrial efficiency Supports exercise performance Why AMPK matters: AMPK is often called the body's metabolic master switch
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If it does not, the most defensible general approach is cold-chain handling: freezer storage for long-term dry powder, refrigerator storage for short-term reconstituted solution, and no casual room-temperature storage after mixing
it does not mask B12 deficiency)
It is not FDA-approved as a drug
BMJ 2021:372
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