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[4] [6] The direct delivery of ascorbic acid into the bloodstream allows for supraphysiological concentrations, which could have distinct biological effects, such as pro-oxidant activity in the presence of transition metals or selective cytotoxicity against certain malignant cells, although these applications remain under investigation and are not universally accepted as standard of care

[42] Diminished SOD3 activity has been linked to lung diseases such as acute respiratory distress syndrome (ARDS) or chronic obstructive pulmonary disease (COPD)

Both diabetes and depression are common chronic conditions which reduce a patients functionality, quality of life and life expectancy

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4583-C THE PRESENCE OF HEPATITIS B CORE ANTIBODY CORRELATES WITH RISK OF CHRONIC KIDNEY DISEASE IN PATIENTS WITH PRIMARY BILIARY CHOLANGITIS Jialiang Chen, Yao Liu, Yufei Bi, Fangyuan Gao and Xianbo Wang, Beijing Ditan Hospital, Capital Medical University, Beijing, China Background: Chronic kidney disease (CKD) is a common comorbidity in patients with chronic liver diseases, especially in chronic hepatitis B and decompensated cirrhosis

Hepatology 43 , 173181 (2006)