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GLP-1 (Glucagon-Like Peptide-1) Delayed gastric emptying (lowers appetite and promotes extended satiation) Increased secretion of insulin Lowered glucose levels GIP (Glucose-dependent Insulinotropic Polypeptide) Increased uptake and storage of glucose Elevated fatty acid uptake Increased secretion of insulin GCG (Glucagon) Elevated lipolysis and energy expenditure Increased secretion of insulin Promotion of satiety (feeling full) Prior work on developing triple receptor agonist molecules shows a synergistic effect between GLP-1, GIP and GCG when said molecule is optimized to adequately target their respective receptors
WONDERBIOTICS is formulated around the role the gut microbiome plays in metabolic health
10.1002/med.21513 187 TrujilloJ
Herskovits, A
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However, these new emergent dual agonists need further investigation to understand the mechanisms of action, how to interact with the respective receptors, increase efficacy, and good safety profile [90,91,92,93,94]
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