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Nat Rev Endocrinol 2021;17:757-66
Future research directions and challenges Development of new derivatives Local delivery system: study the complex of IGF 1 LR3 1mg and hydrogel or nanoparticles to achieve targeted release and reduce systemic side effects
The new dual-agonist Mazdutide quietly fixes that by waking glucagon back uphelping the liver recycle amino acids, burn fat, and protect the brain
Pharmacologically it is a melanocortin receptor agonist with a marked preference for MC4R
10.1186/s40168-021-01181-z 16 HumbertJ
This review takes as a reference clinical trials such as EVOKE, which has not yet published its definitive results, or others such as SELECT, which have already been completed
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