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Ask the prescribing clinician or pharmacist about: Which product is appropriate How often it should be used Potential medication interactions Kidney or heart considerations When persistent symptoms need further evaluation Do not continue stacking laxatives when constipation is accompanied by severe pain, vomiting, abdominal swelling, or inability to pass gas

Report severe upper abdominal pain, especially with persistent vomiting

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Erythrocyte glutamine depletion, altered redox environment, and pulmonary hypertension in sickle cell disease

This might include referral to a dietitian for personalised nutritional guidance, a weight management service for structured support, or mental health services if body image concerns or disordered eating patterns are present

10.2337/db22-er08a 111 SungH.FerlayJ.SiegelR