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Helical peptides that are known to play key roles in maintaining metabolic homeostasis include, among others, glucagon (GCG) and glucagon-like peptide-1 (GLP-1), which signal and agonise the G-protein-coupled receptors (GPCR) GCGR and GLP-1R, respectively 1

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39.9% with placebo), with nausea, vomiting, and diarrhea peaking during dose escalation and declining thereafter, whereas constipation remained relatively constant