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Furthermore, the loss of GPX4 impairs the ability of pharmacological interventions like TA to effectively mitigate ER stress, underlining the importance of GPX4 in maintaining cellular homeostasis under conditions of stress

The residual elements of the extremity can be salvaged to serve their original intended purpose and keeping in mind assessing the importance and likelihood of success of limb salvage in relationship to the patients well-being and other possible disabilities (age, the dominance of hand, loss of a contralateral extremity, blindness, intended future occupation, and patients personal needs) [25]

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Here we have used PV VLPs as a clinically relevant model system to better understand the GSH-binding site as a druggable pocket for the development of antivirals against EVs and as a site for the potential stabilisation of synthetic vaccine candidates

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