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CyC = cyclophosphamide pulses 0.5g/15 day (maximum six pulses)
Subsequently, the authors determined general radiosensitivity ( D 0 dose reducing surviving fraction to 37%), quasi-threshold doses ( D q ), and extrapolation numbers ( n ) from the survival curves and correlated these parameters with the cellular levels of GPx, catalase, CuZn superoxide dismutase (Cu/Zn-SOD), and Mn superoxide dismutase (Mn-SOD)
Concurrently, a decrease in OCR was shown, suggesting a decrease in the activity of the mitochondrial respiratory chain, which is consistent to our results
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In repeated-dose rodent studies, the somatotropic response to hexarelin decreases significantly after several days of consecutive exposure due to receptor desensitization
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