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Key challenges include stability, solubility, permeability, absorption, and protecting the active ingredient through the gastrointestinal tract
The injection is virtually painless
However, evidence remains insufficient
27 This is in contrast to exenatide, which is primarily eliminated through the kidneys, and is not recommended for use in patients with severe renal impairment or in those with end-stage renal disease (ESRD)
Greenfield JR, et al
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