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Yes some lean body mass loss can occur during rapid weight loss on GLP-1 medications
The first two raise both serotonin and norepinephrine, and it is the impact on norepinephrine that is activating
K.AsmarA.MadsbadS.HolstJ
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Most protocols last 48 weeks, followed by a rest period
Safety and Efficacy of Micro-Dosing GLP-1 Medications Clinical Evidence Numerous studies have demonstrated the safety and efficacy of GLP-1 medications in supporting weight loss and wellness treatments
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