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The biology suggests sustained use produces sustained benefit, not just initial improvement followed by tolerance

89 OkabeM.UnnoM.HarigaeH.KakuM.OkitsuY.SasakiT.et al (2005)

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90% of patients achieved more than 5% weight loss compared to 24% on placebo

Ongoing trials are evaluating the optimal sequencing and combination of these agents to further improve outcomes (Fig