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Results should be interpreted alongside clinical presentation, medical history, and provider expertise
Symptoms such as brain fog and hot flashes reflect underlying changes in energy regulation, inflammation, and brain signaling
Note that oral semaglutide (Rybelsus) does not cause injection site reactions
In myeloid cells, GLP-1 medicines also attenuate proinflammatory cytokine release, although these effects appear to be primarily indirect.
An apparent paradox is that whereas GLP-1 increases glucose-stimulated insulin secretion in the isolated pancreas fulfilling the definition of an incretin but it lowers insulin secretion in physiologically relevant conditions [6, 10, 18]
