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The mechanisms underlying IGF-1 LR3's anabolic effects involve activation of the PI3K/Akt/mTOR signaling pathway, which stimulates ribosomal protein S6 and translation initiation factors downstream of mTORC1, thereby enhancing protein synthesis
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Overproduction of NO can occur in several pathological conditions (e.g., inflammation, endotoxic shock, diabetes, ischemia/reperfusion injury
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