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The administration of high doses of lipoic acid by injection to rats decreased the activity of two biotin-dependent enzymes by about 30%-35% (122), but it is not known whether oral or intravenous lipoic acid supplementation substantially increases the requirement for biotin in humans (123)
Graciela E
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Discussion In this study, we investigated metabolomic alterations associated with polyacrylic acid (A45)induced lung injury and fibrosis using CE-TOFMS profiling in a rat intratracheal instillation model
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