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The individual side effect rates (nausea, vomiting, diarrhea) are similar between the two compounds, but the discontinuation rate, which reflects how many people find the side effects intolerable, is significantly lower for semaglutide (5-7%) compared to retatrutide (12-18%)

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This scoping review aimed to identify and describe clinical evidence on renal outcomes associated with GLP-1-based therapies in adults with type 2 diabetes and/or overweight/obesity, with or without CKD