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Its approval followed extensive clinical trials demonstrating safety, bioavailability, GLP-1 receptor engagement, and meaningful weight-related outcomes

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doi: 10.1056/NEJMoa2032183 Ryan DH, Lingvay I, Deanfield J, et al

Experts classify GLP-1 receptor agonists into two types: human GLP-1 backbone agents (e.g., Liraglutide, Dulaglutide, Semaglutide) and exendin-4 backbone agents (e.g., exenatide) (23)