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JAMA surgery
Future Research Directions and Unanswered Questions Despite 50+ years since Pickarts initial isolation work, significant mechanistic and clinical questions remain: Receptor identity: GHK-Cus gene regulatory effects are well-documented, but the specific cellular receptors mediating them remain incompletely characterized
Coffee enemas have almost no scientific backing and have been linked to problems with electrolyte balance, intestinal damage, inflammation, and infection
Several early studies implicated AIFM2 in the regulation of apoptosis
Author contributions XW and YC: contributed to the manuscript writing and analyses
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