doi: 10.3748/wjg.v23.i48.8465
GLP-1 Agonists for NASH Treatment: New Clinical Evidence Reveals Surprising Results Introduction Non-alcoholic fatty liver disease (NAFLD) has emerged as a major global health concern, affecting approximately one in four individuals worldwide
The more clinically important question is how often this produces meaningful perioperative harm, which patients are at highest risk, and how clinicians should balance aspiration prevention against the metabolic, cardiovascular, logistical, and equity-related consequences of withholding therapy
At present, the lack of large-scale, confirmatory clinical trials specifically targeting MC4R deficiency is largely due to significant scientific and clinical heterogeneity, which has made conducting such trials logistically challenging and commercially less appealing compared to pursuing broader or more clearly defined patient populations
Wang, J., Yadav, V., Smart, A
Shanley, L