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AFB1 metabolism studies in human liver microsomal preparations indicate a predominant role for CYP3A4 and that its expression level was an important determinant of the AFB1 disposition in human liver [45]
No Phase 1, Phase 2, or observational human study exists at the time of writing
Managing these side effects might involve lowering the dose, increasing the dose more gradually, splitting the dose, taking the medication with food, or combining spironolactone with a combined oral contraceptive to stabilize menstrual cycles and reduce breakthrough bleeding
Use within 28 days of reconstitution [6]
Whether you choose medication, lifestyle changes alone or a combination approach, the goal is finding a path you can maintain long-term for better health and well-being
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