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(2013, March 17)
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Mooberry LK, Sabnis NA, Panchoo M, Nagarajan B, Lacko AG
doi: 10.1210/clinem/dgz175 4 NauckMAHeimesaatMMOrskovCHolstJJEbertRCreutzfeldtW
GLP-1 has a very short half-life of approximately 1-2 minutes in circulation, as it is rapidly degraded by the enzyme dipeptidyl peptidase-4 (DPP-4)
Two randomized controlled trials in women with hypothalamic amenorrhea have shown conflicting results: one indicated an increase in osteocalcin and N-telopeptides of type 1 collagen (NTX) but no change in BMD [102], while the other revealed increased spine BMD in lean women with hypoleptinemia [101, 103, 104]
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