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Future Perspectives The scientific studies on seleno-GPxs have so far led to the understanding that the physiological role of seleno-GPxs is not only limited to detoxification of peroxides, but also involves regulating signaling pathways (such as chromatin remodulating, NF-B activation, insulin signaling, mitochondrial integrity, and ferroptosis, among others) [1, 8,9,10]

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Given the abundance and diversity of ROS species present within biological systems, cells inevitably perceive and respond to distinct ROS species through specific mechanisms [101], thereby maintaining ROS homeostasis [16]