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The SURPASS-CVOT trial (NCT04255433) will assess the cardiovascular safety of tirzepatide compared to dulaglutide in people with T2D and established atherosclerotic disease [111]

Together, these steps support better glycaemic control and contribute to improved metabolic outcomes

This flexibility helps manage long-term costs

Oral semaglutide versus empagliflozin, sitagliptin and liraglutide in the UK: long-term ost-effectiveness analyses based on the PIONEER clinical Ttial programme

Int J Obes (2012) 36:84354

Drug-drug interactions are uncommon with GLP-1 receptor agonists because they are not metabolized by cytochrome P450 enzymes