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doi:10.2903/j.efsa.2008.815
Mechanism of Action 5-Amino-1MQ acts as a potent and selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme highly expressed in adipose tissue, liver, and certain metabolically active cells
The researchers weren't sure why
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The tightness contribution to the Brnsted alpha for hydride transfer between NAD+ [PMID: 12083929] Laboratory literature summary: The tightness contribution to the Brnsted alpha for hydride transfer between NAD+ analogues
so it should be addressed separately
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