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GLP-1 therapies commonly cause nausea, vomiting, and delayed gastric emptying
Reminder: few foods contain solely one macronutrient
In a system under experiment, this results in: Significant GH secretion signaling
KPV is a tripeptide fragment derived from alpha-melanocyte-stimulating hormone (-MSH), a naturally occurring neuropeptide involved in immune modulation and inflammatory signaling
On GLP-1 medications, you're fighting three dehydration mechanisms simultaneously: Reduced thirst signaling (central appetite suppression affects thirst centers) Reduced fluid intake with meals (nausea makes drinking unpleasant) Ongoing fluid loss from glycogen metabolism during weight loss The result is chronic mild dehydration in a substantial portion of patients during titration
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