In the pancreas, semaglutide stimulates glucose-dependent insulin secretion and suppresses inappropriate glucagon release, thereby improving glycemic control
This means bone was being broken down faster without being rebuilt at a matching rate, a pattern that, if sustained, leads to net bone loss over time
Melanocortin peptide therapeutics: historical milestones, clinical studies and commercialization. Peptides 27(4):921930
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So thanks for that
doi: 10.1210/en.2007-1292 46 KimJYLeeSKJoKJSongDYLimDMParkKYet al