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Chemical degradation of the peptide may theoretically produce breakdown products, though under labeled storage conditions, there is no evidence that semaglutide degradation generates toxic metabolites

1 of 6 males had headaches previously that disappeared after weight loss

But the doses used in fertility studies (especially for men) are usually in the 1,000-3,000 mg per day range

doi: 10.4103/1008-682x.171657

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Precautions & Side Effects While generally safe and well-tolerated, consider the following: Consult a healthcare provider before use if pregnant, nursing, or under medication