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Both methylmalonic acid semialdehydes are converted to propionyl-CoA via the actions of aldehyde dehydrogenase 6 family member A1 (encoded by the ALDH6A1 gene)
Moreover, background therapy, particularly some medications such as thiazolidinediones, sulfonylureas and insulin, could negatively affect the efficacy of OMM in patients with T2D
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Better application of real-world evidence will complement randomised trial evidence
The review further compiles major bioactive compounds and their preclinical evidence suggests roles in immunity, anticancer potential, metabolic health, and vitamin D supplementation
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