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With this latest approval, semaglutide becomes the first pharmacologic therapy available for adults with MASH and fibrosis who do not yet have cirrhosis
In the context of the Melanotan II pathway, this suggests that MC1R-mediated signaling is more likely to function within the expected range, supporting a more typical receptor response to melanocortin-family ligands such as -MSH analogs
Semaglutide works differently, mainly affecting blood sugar levels through its action on the gut and not directly on the kidneys
Both can reduce hunger, increase fullness, and support meaningful weight loss when paired with lifestyle guidance and medical monitoring
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