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~6 days Half-Life (NEJM 2023) ~30 days Full Clearance (5 half-lives) 4-5 weeks Steady State Per Dose Once Weekly Dosing Interval Investigational Status Retatrutide is investigational and not FDA-approved as of April 2026

Patients should be gentle with the area around the puncture site for a couple of days, and can apply an ice pack for 10 to 20 minutes at a time if they notice any bruising or swelling, ensuring a thin cloth is placed between the skin and the ice pack to avoid direct contact

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