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Patients who were prescribed weekly injections of Mounjaro (tirzepatide) were also shown to be more likely to sustain the weight loss results, especially if used as part of a medical weight loss treatment care plan that included regular medical check-ups, the implementation of a new diet, and a new workout regimen

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However, as ActRIIA/B receptors mediate many diverse biologic processes by responding to over a dozen ligands 23,24,25 , there are potential concerns involving chronic long-term blockade of these receptors as a therapeutic approach to increase muscle mass

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The first-line approach involves lifestyle and dietary modifications that reduce reflux triggers and accommodate the altered gastric emptying associated with these medications