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Given the reabsorption of renin by proximal tubule cells through megalin, and the broad expression of ACE within the kidney, allowing locally synthetized ANG II independent action, the interference of SGLT-2-i with intrarenal RAS could explain such results

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Use of retroviral markers to identify efficacy of purging and origin of relapse following autologous bone marrow and peripheral blood cell transplantation in indolent B cell neoplasms (follicular non-Hodgkin's lymphoma or chronic lymphocytic leukemia (CLL) patients)

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DE & Popper, H