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The compound does not have the evidence base that FDA-approved medications or well-established supplements like collagen peptides possess
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Oral administration of AVE3085 for 7 days increases eNOS expression and activity, reverse eNOS uncoupling, reduces oxidative stress and improve endothelial function in diabetic mice (Yang et al., 2011)
The drug is already FDA-approved for the treatment of obesity and diabetes
Oral contraceptives also deplete B6 levels
The Vasireddi review surveys the case-report literature on these uses
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