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The HCA 2 receptor activates an associated G i -type G-protein which inhibits the production of cAMP, thereby reducing the PKA-mediated phosphorylation and activation of hormone-sensitive lipase, HSL

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Destruction of oxidatively-damaged RBCs is accomplished extravascularly by macrophages in the reticuloendothelial system 56

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It is present at millimolar concentrations in every human cell, making it the most abundant intracellular antioxidant and the principal regulator of cellular redox state

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