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As the field advances, humanized preclinical systems that allow drug evaluation against human targetssuch as GCGR/GIPR/GLP1R humanized mouse modelswill play a pivotal role in bridging the gap between mechanistic discovery and clinical translation

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Its also not a shortcut, and its definitely not a replacement for the basics

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based on readout pacing, I would project an NDA filing in late 2026 and a possible approval window in 2027 if results hold